Sign to Strike is a gesture-based web game that explores the potential of gesture-based interaction in sign language learning. It uses real-time ASL fingerspelling recognition to engage players in a fast-paced interactive challenge. Letters fall from the top of the screen, and players must sign the corresponding letter using American Sign Language to destroy them. The game explores the accuracy, responsiveness, and playfulness of sign recognition in dynamic environments. Built with MediaPipe, Matter.js, and p5.js and a pretrained model on python, it combines language, motion, and visual feedback to investigate how physical gestures can drive meaningful and intuitive digital interactions.